Gadolinium-based contrast agents: From gadolinium complexes to colloidal systems
نویسندگان
چکیده
منابع مشابه
New gadolinium complexes as magnetic resonance imaging--contrast agents.
We have investigated the physicochemical and paramagnetic properties of the new gadolinium complexes of N-(pyrid-2-yl-methyl)-ethylenediamine-N,N,N-triacetic acid (Gd-PEDTA) and N-tris(2-aminoethyl)amine-N,N,N,N,N,N+hexaacetic acid(Gd-TTAHA). The relaxivities as well as the thermodynamic and conditional stability constants of these complexes with respect to the physiological relevance were dete...
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Background MRI has dramatically changed the way we diagnose disease. With the introduction of contrast agents specifically for MRI, we were now able to see that which was ‘invisible’. Gadopentetate dimeglumine (Magnevist) was introduced over 20 years ago, since then many more agents with variable features have been introduced. Several newer agents have improved ‘relaxivity’ and some designated ...
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OBJECTIVE Gadolinium neutron capture therapy (GdNCT) is a potential treatment for malignant tumors based on two steps: (1) injection of a tumor-specific (157)Gd compound; (2) tumor irradiation with thermal neutrons. The GdNC reaction can induce cell death provided that Gd is proximate to DNA. Here, we studied the nuclear uptake of Gd by glioblastoma (GBM) tumor cells after treatment with two Gd...
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A series of dendritic gadolinium complexes based on dendrimers with 1,4,7,10-tetraazacyclododecane as the core were synthesized. Both diethylenetriaminepentaacetic acid and pyridoxamine were incorporated to the amine groups on the surface to give the dendritic ligands. These dendritic ligands were then reacted with gadolinium chloride to yield the corresponding dendritic gadolinium complexes. T...
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Nephrogenic systemic fibrosis (NSF), previously known as nephrogenic fibrosing dermopathy, is an emerging systemic fibrosing disorder that develops in the setting of renal insufficiency. Nephrogenic fibrosing dermopathy (NFD) is a fibrosing condition of the skin which shows an increased number of dendritic cells, fibroblasts and thickened collagen fibers resembling scleromyxedema. It is charact...
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutics
سال: 2019
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2019.118577